La cardiopatía isquémica en pacientes diabéticos y no diabéticos / Ischemic heart disease in diabetic and non-diabetic patients

Introducción: La cardiopatía isquémica tiene como uno de sus factores de riesgo más importante a la Diabetes mellitus, la cual influye en el pronóstico, tratamiento, severidad, morbilidad y mortalidad de esta enfermedad. Objetivo: Caracterizar la influencia de la Diabetes mellitus en la cardiopatía isquémica. Material y Métodos: Se realizó una revisión bibliográfica sobre la temática. Resultados: La Diabetes mellitus es un factor de riesgo de alta relevancia de la cardiopatía isquémica. Las personas con diabetes corren el mismo riesgo de tener un infarto de miocardio que las personas sin diabetes que ya han tenido uno. Las mujeres diabéticas son más propensas a cardiopatías isquémicas. Existe una mayor frecuencia de Diabetes mellitus en los pacientes portadores de la cardiopatía isquémica con edades entre 45 y 80 años. Conclusiones: La diabetes impone mayor riesgo de padecer cardiopatía isquémica, la hace más precoz, le impone dificultades diagnósticas y mayor riesgo de complicaciones. La diabetes y la cardiopatía isquémica son enfermedades con incidencias y prevalencias que se incrementan con la edad(AU)

Introduction:Ischemic heart disease has Diabetes mellitus as one of its most important factors, because affects the prognosis, treatment, severity, morbidity and mortality of the first one. Objective: To characterize the influence of diabetes mellitus on ischemic heart disease. Material and Methods: A literature review on the subject was conducted. Results: Diabetes mellitus is confirmed as a highly relevant risk factor for ischemic heart disease. People with diabetes are at the same risk of having a myocardial infarction as people without diabetes who have already had one. Diabetic women are more likely to have ischemic heart disease. There is a higher frequency of Diabetes mellitus in patients with ischemic heart disease aged between 45 and 80 years. Conclusions:Diabetes imposes an increased risk of suffering of ischemic heart disease, makes it more precocious, and imposes diagnostic difficulties and greater risk of complications. Diabetes and ischemic heart disease are illnesses with incidence and prevalence that increase with age(AU)

Intramyocardial gene transfer of vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic in vitro and in vivo. Several studies report on gene transfer of VEGF121 to promote angiogenesis in the ischemic myocardium of animals and patients. We hypothesized that intramyocardial administration of naked plasmid DNA encoding VEGF121 could improve myocardial perfusion and function in a porcine model of myocardial ischemia. Yorkshire swine underwent thoracotomy and placement of an ameroid constrictor on the circumflex coronary artery. Four weeks later, pVEGF121 plasmid was administered into the ischemic myocardium. Four weeks after gene transfer, SPECT imaging demonstrated significant reduction in the ischemic area in pVEGF121-treated animals compared with controls. In the pVEGF121 group, most of the animals evolved from light ischemia to a normal perfusion. In contrast, control animals exhibited similar or impaired ischemic conditions. Our results indicate that intramyocardial gene transfer of VEGF121 as naked plasmid DNA results in significant improvement in myocardial perfusion and function.